Table 2 Clinical characteristics comparing children with and without a rare genetic variant
From: Psychopharmacology in children with genetic disorders of epigenetic and chromatin regulation
| Â | Any genetic variant | No genetic variant reported | p |
|---|---|---|---|
n | 32 (10%) | 299 (90%) | Â |
Demographic characteristics | |||
 Female Sex, N(%) | 9 (28%) | 48 (16%) | 0.1 |
 Age at first visit, Mean (SD) | 11.0 (3.1) | 10.6 (3.1) | 0.5 |
 Number of follow-up visits, Mean (SD) | 8.2 (5.0) | 8.2 (6.3) | 0.9 |
 Follow-up time in years, Mean (SD) | 3.8 (3.2) | 3.4 (3.1) | 0.5 |
Co-occurring developmental and psychiatric conditions | |||
 Intellectual Disability, N (%) | 18 (56%) | 92 (31%) | 0.007* |
 Autism diagnosis, N (%) | 26 (81%) | 274 (94%) | 0.09 |
 ADHD diagnosis, N (%) | 16 (50%) | 171(57%) | 0.5 |
 Non-speaking, N (%) | 11 (34%) | 68 (23%) | 0.2 |
 Past crisis service use for behaviour, N (%) | 4 (13%) | 47 (16%) | 0.8 |
 Aggressive behaviour, N (%) | 22 (69%) | 215 (72%) | 0.7 |
 Self-injurious behaviour, N (%) | 14 (44%) | 140 (47%) | 0.8 |
Medical history | |||
 Number of subspecialist physicians, Mean (SD) | 3.3 (2.6) | 1.2 (1.4) |  < 0.001 |
 Number of physical health conditions, Mean (SD) | 1.6 (0.9) | 1.1 (0.5) |  < 0.001 |
 Seizures, N (%) | 13 (40%) | 34 (11%) |  < 0.001 |
 Obesity, N (%) | 12 (38%) | 84 (28%) | 0.3 |
 Asthma, N (%) | 2 (6%) | 12 (4%) | 0.6 |
 GERD, N (%) | 7 (22%) | 7 (2%) |  < 0.001* |
 Chronic constipation, N (%) | 2 (6%) | 16 (5%) | 0.7 |