Fig. 8

Genotype difference in ITPC was found in frontal, but not auditory, cortex at P30. NLX-101 increased ITPC in Fmr1 WT and KO mice. A-B) No genotype difference in gap-ASSR ITPC was found in the auditory cortex, but ITPC was significantly lower in the frontal cortex of Fmr1 KO mice compared with WT controls. C-F) Acute NLX-101 administration significantly increased ITPC in both auditory and frontal cortex. Besides, NLX-101 increased ITPC as gap width increases in the frontal cortex (gap width x treatment interaction). WT exhibited higher ITPC than KO at longer gap widths (gap width x genotype interaction). Full statistics report is in Table 5. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Error bars show standard deviation