Fig. 4

STP is significantly higher in Fmr1 KO mice compared with WT at P30, and NLX-101 reduced elevated STP in Fmr1 KO mice without affecting WT mice. The details of this figure are similar to those described in Fig. 3. A-B) Comparison of saline treated KO and WT mice shows a significant genotype effect on STP at P30. Fmr1 KO mice have elevated STP in both auditory and frontal cortex compared with WT mice. C-D) STP in Fmr1 KO mice was significantly reduced after NLX-101 compared with saline treated KO mice. E-F) Comparison between KO NLX-101 treated group and WT saline treated group. No difference was seen, suggesting NLX-101 reduced elevated STP in Fmr1 KO mice to the level that is indistinguishable from WT mice. G-H) No treatment effect of NLX-101 was seen in WT mice in either cortical region suggesting NLX-101 effects on STP are specific to Fmr1 KO mice. The measurement unit for STP is in µV²/Hz