Fig. 3

STP is significantly elevated in Fmr1 KO mice compared with WT at P21, and NLX-101 failed to correct this phenotype. In A through F, the two smaller panels at the top show grand averaged ERP (as traces) and STP (as heatmaps) from each group. The larger panel at the bottom shows the STP difference between the two groups of mice. The vertical dashed line shows sound onset. The contoured area in the larger panels show regions of significant differences between the group being compared. Warm colors show elevated STP, and cool colors show a reduction in the difference plots. A-B) Comparison of saline treated KO and WT mice shows a significant genotype effect on STP at P21. Fmr1 KO mice have elevated STP in both auditory and frontal cortex compared with WT mice. C-D) Comparison of NLX-101 and saline treated Fmr1 KO mice shows there was no treatment effect in either cortical region at P21. E-F) No treatment effect of NLX-101 was seen in WT mice either. The measurement unit for STP is in µV²/Hz