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Table 2 Altered nodal profiles in GHD and typically developing controls

From: Altered individual-level morphological similarity network in children with growth hormone deficiency

Brain regions

Category

P-value

\({D}_{i}^{auc}\)

\({E}_{i}^{auc}\)

\({B}_{i}^{auc}\)

GHD > TDs

 IFGoperc.L

CEN

0.033*

0.439

0.007*

 ORBinf.L

CEN

0.010**

0.011*

0.862

 ACG.R

Limbic

0.009*

0.044*

0.804

 PCG.R

Limbic

0.047*

0.607

0.002**

 HIP.L

Limbic

0.088

0.455

0.022**

 PAL.L

Striatum

0.064

0.257

<0.001**

 PAL.R

Striatum

0.001**

0.009*

0.004*

 THA.L

Thalamus

0.005**

0.032*

0.823

 THA.R

Thalamus

0.005**

0.019**

0.167

 Cbe4-5.L

Cerebellum

0.014*

0.034*

0.365

 Cbe4-5.R

Cerebellum

0.001**

0.010**

0.420

 Cbe6.R

Cerebellum

0.005*

0.032*

0.614

GHD < TDs

 ORBsupmed.L

DMN

0.008*

0.015**

0.021*

 AMYG.L

Limbic

0.006*

0.034**

0.015*

 AMYG.R

Limbic

0.005**

0.001**

0.192

 LING.R

VN

0.042*

0.034**

0.846

 PCL.L

SMN

0.016*

0.001**

0.433

 PCL.R

SMN

0.104

0.034**

0.251

 STG.R

AN

0.120

0.034**

0.257

 Cbe3.L

Cerebellum

0.027*

0.015*

0.686

 Cbe3.R

Cerebellum

<0.001**

<0.001**

0.009*

 Cbe10.L

Cerebellum

0.614

0.034**

0.348

 Cbe10.R

Cerebellum

0.404

0.021**

0.153

 Ver1-2

Cerebellum

<0.001**

<0.001**

0.003**

 Ver3

Cerebellum

<0.001**

<0.001**

<0.001**

 Ver4-5

Cerebellum

0.021**

0.001**

0.234

 Ver6

Cerebellum

0.006*

0.021**

0.561

  1. 27 regions with P-value <0.05 in at least one node profile were included.
  2. Abbreviations:\({D}_{i}^{auc}\) nodal degree, \({E}_{i}^{auc}\) nodal efficiency, \({B}_{i}^{auc}\) nodal betweenness, GHD growth hormone deficiency, TDs typically developing controls, L left, R right, IFGoperc Inferior frontal gyrus, opercular part, ORBinf Inferior frontal gyrus, orbital part, ACG Anterior cingulate and paracingulate gyri, PCG Posterior cingulate gyrus, HIP Hippocampus, PAL Lenticular nucleus, pallidum, THA Thalamus, Cbe4-5 Cerebellum 4-5, Cbe6 Cerebellum 6, ORBsupmed Superior frontal gyrus, medial orbital, AMYG Amygdala, LING Lingual gyrus, PCL Paracentral lobule, STG Superior temporal gyrus, Cbe3 Cerebellum 3, Cbe10 Cerebellum 10, Ver1-2 Vermis 1-2, Ver3 Vermis 3, Ver4-5 Vermis 4-5, Ver6 Vermis 6, CEN central executive network, SMN sensorimotor network, DMN default-mode network, SN salience network, VN visual network, AN auditory network
  3. *Uncorrected P < 0.05; **PFDR < 0.05
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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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