Fig. 3
From: Unraveling neuronal and metabolic alterations in neurofibromatosis type 1
Nf1 regulates molecular functions in key biological signaling pathways via Ras. Nf1 affects diverse cellular functions by regulating several signaling pathways. Nf1 accelerates the conversion of active GTP-bound Ras into inactive GFP-bound Ras, thereby regulating numerous downstream effectors. Known signaling pathways downstream of Nf1 and Ras signaling include the Raf/MEK/ERK and PI3K/AKT/mTOR pathways. Figure created with BioRender.com and adapted from Anastasaki et al. (2022) [60], Masgras and Rasola (2021) [66], and Ratner and Miller (2015) [26]