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Table 3 Subcortical and global volumetric ratios of the participants

From: Volumetric brain reductions in adult patients with phenylketonuria and their relationship with blood phenylalanine levels

 

HC n = 22

PKU/HPA n = 35

Statistics

p-value

pFDR

Thalamus

0.532 ± 0.056

0.519 ± 0.045

340.000U

0.461

0,421

Caudate

0.245 ± 0.030

0.237 ± 0.023

351.000U

0.577

0,357

Putamen

0.343 ± 0.039

0.332 ± 0.028

1.239t

0.221

0,327

Pallidum

0.142 ± 0.014

0.133 ± 0.012

224.000U

0.008*

0,031*

Hippocampus

0.293 ± 0.034

0.273 ± 0.023

243.000U

0.020*

0,031*

Amygdala

0.116 ± 0.012

0.108 ± 0.009

200.000U

0.002*

0,013*

Accumbens

0.034 ± 0.006

0.033 ± 0.004

0.656t

0.515

0,508

Brainstem

1.510 ± 0.172

1.390 ± 0.116

3.172t

0.006*

0,013*

Cortical gray matter

33.363 ± 3.195

32.097 ± 2.166

289.000U

0.116

0,685

Subcortical gray matter

4.069 ± 0.379

3.885 ± 0.236

294.000U

0.136

0,056

Cerebral white matter

15.883 ± 1.565

14.676 ± 1.129

175.000U

0.001*

0,013*

Mean cortical thickness

2.521 ± 0.080

2.535 ± 0.068

-0.723t

0.236

0,507

Total estimated intracranial volume (cm3)

1443.684 ± 198.753

1509.057 ± 187.899

-1.251t

0.216

0,327

  1. Values denote the mean ± SD of volumetric ratio scores
  2. Statistical tests used: tt-test, UMann-Whitney, FDR correction
  3. Abbreviations: HC healthy controls, PKU/HPA patients with phenylketonuria/hyperphenylalaninemia
  4. *Statistical significance highlight, treshold set at p<0.05