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Table 2 Neuropsychological performance of the participants

From: Volumetric brain reductions in adult patients with phenylketonuria and their relationship with blood phenylalanine levels

 

HC n = 22

PKU/HPA n = 35

statistics

p-value

pFDR

Vocabulary

38.27 ± 5.650

34.66 ± 7.447a

246.500U

0.063

0.090

Similarities

25.05 ± 3.848

23.19 ± 3.831a

248.500U

0.067

0.104

VCI

116.14 ± 15.050

108.06 ± 13.320a

2.076t

0.043*

0.090

Block design

44.64 ± 8.295

44.66 ± 11.545

-0.007t

0.994

0.996

Matrix reasoning

21.23 ± 2.468

19.34 ± 4.051

286.500U

0.103

0.346

PRI

102.45 ± 12.439

96.89 ± 13.503

1.562t

0.124

0.422

Digit

25.14 ± 4.804

24.74 ± 4.415

384.000U

0.987

0.926

Forward

8.64 ± 2.128

8.49 ± 1.652

385.000U

1.000

0.926

Backwards

8.95 ± 2.149

8.74 ± 1.853

366.000U

0.752

0.926

Sequencing

7.55 ± 1.471

7.51 ± 1.755

380.500U

0.940

0.996

Arithmetic

13.18 ± 2.373

11.81 ± 3.267a

261.000U

0.107

0.120

Letter-number sequencing

19.27 ± 2.529

18.54 ± 2.267

295.500U

0.139

0.480

WMI

95.32 ± 11.721

89.63 ± 14.334

299.500U

0.159

0.442

Symbol search

33.23 ± 5.589

32.34 ± 7.662

0.503t

0.617

0.909

Digit-symbol coding

78.27 ± 12.456

70.74 ± 14.650

1.998t

0.051

0.346

PSI

104.77 ± 11.351

98.17 ± 11.610

271.500U

0.061

0.346

Fluency tests

Semantic (animals)

24.77 ± 3.963

22.68 ± 5.470b

270.500U

0.082

0.179

Phonetic (letter P)

16.05 ± 4.134

14.68 ± 3.470b

311.500U

0.292

0.179

TMT

Part A

28.68 ± 8.855

31.89 ± 9.588

312.000U

0.321

0.480

Part B

68.50 ± 25.194

70.69 ± 20.786

360.000U

0.682

0.926

FSIQ

105.95 ± 12.167

97.34 ± 11.307a

2.666t

0.010*

0.035*

RAVLT

Total

54.09 ± 6.575

51.00 ± 8.363

312.500U

0.234

0.422

Recall

11.77 ± 1.688

11.06 ± 2.555

323.000U

0.305

0.480

ROCF

Copy

32.909 ± 2.580

32.771 ± 3.828

368.500U

0.231

0.926

Immediate recall

21.818 ± 6.563

21.471 ± 5.326

0.219t

0.828

0.946

BRIEF

109.88 ± 17.885

107.21 ± 20.898

917.000U

0.577

0.577

BRIEF, altered (%)

3 (13.636%)

3 (8.571%)

0.368X2

0.544

0.577

  1. Values denote the mean ± SD of raw scores and index of the WAIS-IV
  2. Statistical tests used: X2Chi-Squared, tt-test, UMann-Whitney, FDR correction
  3. Abbreviations: BRIEF Behavior Rating Inventory of Executive Function for Adults, FSIQ Full Scale IQ, HC healthy controls, PKU/HPA patients with phenylketonuria/hyperphenylalaninemia, PRI Perceptual Reasoning Index, PSI Processing Speed Index, RAVLT Rey Auditory Verbal Learning Test, ROCF Rey-Osterrieth Complex Figure, TMT Trail Making Test, VCI Verbal Comprehension Index, WMI Working Memory Index
  4. *Statistical significance highlight, threshold set at p < 0.05
  5. an = 32
  6. bn = 34