Table 2 Differences in brain volumes at term equivalent age between the improving and delayed improvement groups
| Â | Respiratory Trajectories | Â | Â | |
|---|---|---|---|---|
Improving | Delayed improvement | |||
|  | n = 31 | n = 48 | P-value |  |
Demographics | Â | Â | Â | Â |
Male, n (%) | 19 (61.3) | 27 (56.3) | 0.66 | Â |
PMA at MRI, wks, mean (SD) | 41.5 (3.7) | 42.5 (4.7) | 0.34 | Â |
Structural brain volume, cm3, mean (SD) | Â | Â | P-value | Adjusted P-value* |
Intracranial volume (ICV) | 484.3 (97.4) | 451.5 (111.0) | 0.18 | 1.00 |
Total brain volume (TBV) | 385.9 (71.8) | 357.2 (88.3) | 0.13 | 1.00 |
Total tissue volume (TTV) | 378.1 (69.5) | 347.6 (86.9) | 0.10 | 1.00 |
TTV minus Brainstem and cerebellum | 344.9 (60.5) | 317.2 (75.0) | 0.09 | 1.00 |
TTV/ICV ratio | 0.78 (0.03) | 0.77 (0.04) | 0.18 | Â |
TTV minus/ICV ratio | 0.72 (0.03) | 0.71 (0.04) | 0.27 | Â |
Brainstem | 6.6 (1.0) | 6.2 (1.3) | 0.15 | 1.00 |
Cerebellum | 26.7 (8.6) | 24.4 (11.4) | 0.34 | 1.00 |
Extra-axial cerebrospinal fluid | 98.4 (31.4) | 94.4 (28.3) | 0.56 | 1.00 |
Ventricles | 7.7 (3.3) | 9.1 (6.2) | 0.25 | 1.00 |
Cortical gray matter | 162.0 (40.4) | 149.7 (48.1) | 0.24 | 1.00 |
Cortical white matter | 162.1 (19.3) | 147.9 (28.0) | 0.009 | 0.15 |
Subcortical gray nuclei | 22.8 (3.8) | 21.9 (4.3) | 0.34 | 1.00 |
Lobe brain volumes | Â | Â | Â | Â |
Frontal lobe | 117.0 (20.7) | 106.4 (25.1) | 0.05 | 0.85 |
Parietal lobe | 77.8 (14.9) | 70.8 (18.6) | 0.09 | 1.00 |
Temporal lobe | 49.6 (8.4) | 48.0 (13.2) | 0.52 | 1.00 |
Occipital lobe | 48.0 (9.4) | 45.3 (10.9) | 0.26 | 1.00 |
Insula | 8.9 (1.3) | 8.3 (2.9) | 0.30 | 1.00 |
Limbic lobe | 20.9 (3.8) | 19.4 (4.5) | 0.14 | 1.00 |