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Table 3 Unadjusted and adjusted odds ratios for associations between sOT use and reported autism spectrum disorder (ASD) diagnosis

From: Intrapartum exposure to synthetic oxytocin, maternal BMI, and neurodevelopmental outcomes in children within the ECHO consortium

 

ASD/

no ASD

OR (95% CI)

Total Sample

851/11,652

 

Unadjusted a

 

0.86 (0.72, 1.03)

Adjusted b

 

0.87 (0.72, 1.05)

Adjusted b + Obese

 

0.86 (0.71, 1.04)

Adjusted b + GDM

 

0.87 (0.72, 1.04)

Adjusted b + Obese + GDM

 

0.86 (0.71, 1.03)

Males

654/5,906

 

Unadjusted a

 

0.85 (0.69, 1.04)

Adjusted c

 

0.83 (0.67, 1.03)

Adjusted c + Obese

 

0.82 (0.66, 1.01)

Adjusted c + GDM

 

0.82 (0.66, 1.02)

Adjusted c + Obese + GDM

 

0.81 (0.65, 1.01)

Females

197/5,746

 

Unadjusted a

 

0.92 (0.65, 1.29)

Adjusted c

 

0.99 (0.69, 1.42)

Adjusted c + Obese

 

0.98 (0.68, 1.40)

Adjusted c + GDM

 

0.99 (0.69, 1.41)

Adjusted c + Obese + GDM

 

0.97 (0.68, 1.39)

  1. ADHD, attention deficit hyperactivity disorder; ASD, autism spectrum disorder; CI, confidence interval; GDM, gestational diabetes mellitus; OR, odds ratio; sOT, synthetic Oxytocin
  2. a Regression included random intercept for ECHO cohort membership
  3. b Regression adjusted for maternal age at delivery, maternal highest education level, child race, ethnicity, and sex, child birth year, gestational age at birth and large for gestational age with random intercept for ECHO cohort membership
  4. cRegression adjusted for maternal age at delivery, maternal highest education level, child race, ethnicity, child birth year, gestational age at birth and large for gestational age with random intercept for ECHO cohort membership