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Table 1 Characteristics of children and mothers according to sOT exposure status, ECHO study (N = 12,503)

From: Intrapartum exposure to synthetic oxytocin, maternal BMI, and neurodevelopmental outcomes in children within the ECHO consortium

 

sOT exposed

n (%)

sOT unexposed

n (%)

P-value

Total

6,014 (48%)

6,489 (52%)

 

Child characteristics

   

ASD diagnosis, N (%) with data

  

0.001

No

5,558 (92.42%)

6,094 (93.91%)

 

Yes

456 (7.58%)

395 (6.09%)

 

Missing

0

0

 

Child age at ASD diagnosis

  

< 0.001

Mean (SD)

3.00 (2.49)

3.86 (3.00)

 

Missing

35

44

 

ADHD diagnosis, N (%) with data

  

< 0.001

No

5,586 (92.88%)

5,844 (90.06%)

 

Yes

428 (7.12%)

645 (9.94%)

 

Missing

0

0

 

Child age at ADHD diagnosis

  

0.120

Mean (SD)

7.10 (2.93)

6.81 (2.66)

 

Missing

54

54

 

Child sex at birth, N (%) with data

  

0.221

Male

3,190 (53.04%)

3,370 (51.93%)

 

Female

2,824 (46.96%)

3,119 (48.07%)

 

Missing

0

0

 

Child race, N (%) with data

  

< 0.001

American Indian or Alaska Native

56 (< 1%)

148 (2.35%)

 

Asian

345 (5.94%)

249 (3.96%)

 

Black

1,135 (19.55%)

1,197 (19.02%)

 

Multiple race

765 (13.18%)

676 (10.74%)

 

Native Hawaiian or other Pacific Islander

21 (< 1%)

11 (< 1%)

 

Other race

192 (3.31%)

180 (2.86%)

 

White

3,292 (56.7%)

3,833 (60.9%)

 

Missing

208

195

 

Child ethnicity, N (%) with data

  

< 0.001

Hispanic

1,464 (24.53%)

1,321 (20.47%)

 

Non-Hispanic

4,504 (75.47%)

5,133 (79.53%)

 

Missing

46

35

 

Preterm birth, N (%) with data

  

< 0.001

Yes

546 (9.09%)

1,311 (20.23%)

 

No

5,461 (90.91%)

5,168 (79.77%)

 

Missing

7

10

 

Gestational age at birth (weeks)

  

< 0.001

Mean (SD)

38.60 (2.56)

37.16 (4.50)

 

Missing

23

31

 

Large for gestational age, N (%) with data

  

0.658

Yes

969 (16.29%)

1,052 (16.6%)

 

No

4,980 (83.71%)

5,285 (83.4%)

 

Missing

65

152

 

Child year of birth, N (%) with data

  

< 0.001

<2005

441 (7.33%)

495 (7.63%)

 

2006–2010

1,075 (17.87%)

1,231 (18.97%)

 

2011–2015

1,775 (29.51%)

2,630 (40.53%)

 

2016–2022

2,723 (45.28%)

2,133 (32.87%)

 

Missing

0

0

 

Maternal characteristics

   

Maternal age at delivery

  

0.524

Mean (SD)

29.84 (5.61)

29.91 (5.62)

 

Missing

18

31

 

Maternal race, N (%) with data

  

< 0.001

American Indian or Alaska Native

55 (< 1%)

170 (2.75%)

 

Asian

473 (8.35%)

328 (5.31%)

 

Black

1,125 (19.85%)

1,182 (19.14%)

 

Multiple race

306 (5.4%)

297 (4.81%)

 

Native Hawaiian or other Pacific Islander

27 (< 1%)

17 (< 1%)

 

Other race

182 (3.21%)

170 (2.75%)

 

White

3,499 (61.74%)

4,013 (64.97%)

 

Missing

347

312

 

Maternal ethnicity, N (%) with data

  

< 0.001

Hispanic

1,199 (20.12%)

1,090 (16.96%)

 

Non-Hispanic

4,759 (79.88%)

5,337 (83.04%)

 

Missing

56

62

 

Highest maternal education ever assessed,

N (%) with data

  

0.014

High school degree, GED or

equivalent and below

959 (16.13%)

1,149 (18.1%)

 

Some college, no degree; Associate’s degree

1,771 (29.79%)

1,822 (28.7%)

 

Bachelor’s degree and above

3,214 (54.07%)

3,378 (53.21%)

 

Missing

70

140

 

Pre-pregnancy obesity, N (%) with data

  

0.014

Yes

1,553 (28.75%)

1,548 (26.67%)

 

No

3,848 (71.25%)

4,257 (73.33%)

 

Missing

613

684

 

Gestational diabetes mellitus, N (%) with data

  

< 0.001

Yes

531 (9.02%)

381 (7.24%)

 

No

5,359 (90.98%)

4,884 (92.76%)

 

Missing

124

1,224

 
  1. ADHD, attention deficit hyperactivity disorder; ASD, autism spectrum disorder; ECHO, Environmental influences on Child Health Outcomes; GED, general education development; NICU, neonatal intensive care units; SD, standard deviation; sOT, synthetic Oxytocin