The feasibility and utility of hair follicle sampling to measure FMRP and FMR1 mRNA in children with or without fragile X syndrome: a pilot study

Table 7 Relationship between FMR1 mRNA levels and GARS-3 score at visit 1 — Pearson correlation coefficients

			GARS-3 Emotional Response		GARS-3 Social Communication		GARS-3 Restricted/Repetitive Behavior		GARS-3 Social Interaction		GARS-3 Cognitive Style		GARS-3 Maladaptive Speech
Collection
Group	type	n	Pearson’s r	p-value	Pearson’s r	p-value	Pearson’s r	p-value	Pearson’s r	p-value	Pearson’s r	p-value	Pearson’s r	p-value
FXS participant (N = 9)	Buccal swab	7	−0.343	0.452	0.15496	0.740	−0.335	0.463	−0.024	0.959	0.133	0.802	−0.436	0.388
	Hair follicle	8	−0.227	0.589	0.26244	0.530	0.518	0.188	−0.125	0.768	0.542	0.209	0.642	0.120
	Blood	7	−0.207	0.656	−0.19646	0.673	−0.555	0.196	−0.084	0.857	−0.234	0.613	−0.702	0.079
Healthy participant (N = 5)	Buccal swab	4	nc		0.97289	0.027	nc		nc		0.890	0.110		nc
	Hair follicle	5	0.763	0.133	−0.48042	0.413	nc		nc		−0.120	0.848		nc
	Blood	4	−0.492	0.508			nc		nc		0.169	0.831		nc

Notes: For the hair follicle and buccal swab collection types, the mean FMR1 mRNA Delta Cq value across all samples is correlated with each OWLS-II score or each GARS-3 score. For the blood collection type, two relative FMR1 values were reported for subjects 101-002, 101-005, and 101-007; only the smallest value for each subject is used in correlations
Abbreviations: GARS-3 Gilliam Autism Rating Scale 3rd Edition, nc not calculable OWLS-II Oral and Written Language Scale 2nd Edition

ISSN: 1866-1955