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Table 3 Clinical features of participants based on treatment recorded in medication logs

From: Anxiety-like behavior and anxiolytic treatment in the Rett syndrome natural history study

Study

Feature

Any anxiolytic

SSRI

Yes

No

Significance

Yes

No

Significance

First iteration (n= 1068)

Age (years)

11.3 ± 9.7

8.7 ± 8.6

P < 0.000*

11.3 ± 9.8

8.76 ± 8.6

P < 0.000*

CSS total score

19.9 ± 7.1

22.6 ± 7.8

P < 0.000*

18.9 ± 6.9

22.7 ± 7.8

P < 0.000*

MBA total score

44.0 ± 14.1

47.4 ± 15.1

P = 0.006*

43.8 ± 14.0

47.4 ± 15.1

P = 0.006*

Second iteration (n= 662)

Age (years)

18.7 ± 10.6

14.6 ± 10.6

P < 0.000*

20.2 ± 10.6

14.5 ± 10.5

P < 0.000*

CSS total score

24.0 ± 7.1

23.8 ± 8.5

P = 0.790

23.0 ± 7.2

23.9 ± 8.4

P = 0.324

MBA total score

49.7 ±13.7

48.6 ± 13.8

P = 0.487

48.3 ± 10.7

48.8 ± 14.1

P = 0.710

  1. Values are reported as mean ± standard deviation
  2. CSS Clinical Severity Scale, First iteration Subjects enrolled 2006–2015, MBA Motor Behavioral Assessment, Second iteration Subjects enrolled 2015–2019
  3. *P statistically significant
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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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